Selected Publications

2026:

Lu G, Zhang S, Feng M, Kim E, Cho D, Kim JH, Caris H, Silberstein L, Choi GB, Huh JR. In vivo detection of immune responses via cytokine activity labeling. Cell. 2026 Jan 7:S0092-8674(25)01424-2. doi: 10.1016/j.cell.2025.12.011. Epub ahead of print. PMID: 41506266.

Yang L, Andina ML, Witkowski M, King H, Wickersham I, Huh JR, Choi GB. IL-1R1-positive dorsal raphe neurons drive self-imposed social withdrawal in sickness. Cell. 2026 Jan 8;189(1):272-286.e19. doi: 10.1016/j.cell.2025.10.040. Epub 2025 Nov 25. PMID: 41297539.

2025:

Tran M, Huh JR, Devlin AS. The role of gut microbial metabolites in the T cell lifecycle. Nat Immunol. 2025 Jul 21. doi: 10.1038/s41590-025-02227-2. Epub ahead of print. PMID: 40691327.

Cho DH, Huh JR, Choi GB. Neuromodulation by the immune system: implications for brain-directed immunotherapy. Curr Opin Immunol. 2025 Aug;95:102568. doi: 10.1016/j.coi.2025.102568. Epub 2025 Jun 6. PMID: 40483766.

Lee, Yunjin; Ishikawa, Tomoe; Lee, Hyeseung; Lee, Byeongjun; Ryu, Changhyeon; Davila Mejia, Irene; Kim, Minjin; Lu, Guangqing; Hong, Yujin; Feng, Mengyang; Shin, Hyeyoon; Meloche, Sylvain; Locksley, Richard M.; Koltsova, Ekaterina; Grivennikov, Sergei I.; Heiman, Myriam; Choi, Gloria B.; Huh, Jun R. Brain-wide mapping of immune receptors uncovers a neuromodulatory role of IL-17E and the receptor IL-17RB. Cell. 2025 April 07. doi: 10.1016/j.cell.2025.03.006

2024:

Lee KH, Kim YO, Dho SH, Yong JJH, Oh HS, Lee JH, Yang SJ, Cha I, Chun J, Lee EH, Jeong SJ, Woo W, Choi JP, Han SH, Choi GB, Huh JR, Kim LK, Song YG. Altered gut microbiome in convalescent patients with coronavirus disease 2019. Front Cell Infect Microbiol. 2024 Nov 28;14:1455295. doi: 10.3389/fcimb.2024.1455295.

Oh DS, Kim E, Normand R, Lu G, Shook LL, Lyall A, Jasset O, Demidkin S, Gilbert E, Kim J, Akinwunmi B, Tantivit J, Tirard A, Arnold BY, Slowikowski K; MGH COVID-19 Collection & Processing Team; Goldberg MB, Filbin MR, Hacohen N, Nguyen LH, Chan AT, Yu XG, Li JZ, Yonker L, Fasano A, Perlis RH, Pasternak O, Gray KJ, Choi GB, Drew DA, Sen P, Villani AC, Edlow AG, Huh JR. SARS-CoV-2 infection elucidates features of pregnancy-specific immunity. Cell Rep. 2024 Nov 26;43(11):114933. doi: 10.1016/j.celrep.2024.114933.

McCurry MD, D'Agostino GD, Walsh JT, Bisanz JE, Zalosnik I, Dong X, Morris DJ, Korzenik JR, Edlow AG, Balskus EP, Turnbaugh PJ, Huh JR, Devlin AS. Gut bacteria convert glucocorticoids into progestins in the presence of hydrogen gas. Cell. 2024 Jun 6;187(12):2952-2968.e13. doi: 10.1016/j.cell.2024.05.005.

2022:

Yang D, Jacobson A, Meerschaert KA, Sifakis JJ, Wu M, Chen X, Yang T, Zhou Y, Anekal PV, Rucker RA, Sharma D, Sontheimer-Phelps A, Wu GS, Deng L, Anderson MD, Choi S, Neel D, Lee N, Kasper DL, Jabri B, Huh JR, Johansson M, Thiagarajah JR, Riesenfeld SJ, Chiu IM. Nociceptor neurons direct goblet cells via a CGRP-RAMP1 axis to drive mucus production and gut barrier protection. Cell. 2022 Oct 27;185(22):4190-4205.e25. doi: 10.1016/j.cell.2022.09.024.

Yao L, D'Agostino GD, Park J, Hang S, Adhikari AA, Zhang Y, Li W, Avila-Pacheco J, Bae S, Clish CB, Franzosa EA, Huttenhower C, Huh JR, Develin AS A biosinyhtic pathway for the selective sulfonation of steroidal metabolities by human gut bacteria. Nature Microbiology 2022 Aug. doi: 10.1038/s41564-022-01176-y

Paik D, Yao L, Zhang Y, Bae S, D'Agostino G, Zhang M, Kim E, Franzosa EA, Avila-Pacheco J, Bisanz JE, Rakowski CK, Vlamakis H, Xavier RJ, Turnbaugh PJ, Longman RS, Krout MR, Clish CB, Rastinejad F, Huttenhower C, Huh JR*, Devlin AS* Human gut bacteria produce TH17-modulating bile acid metabolites. Nature. 2022 Mar. doi: 10.1038/s41586-022-04480-z

Kwon HK, Choi GB, Huh JR*. Maternal inflammation and its ramifications on fetal neurodevelopment. Trends Immunol. 2022 Mar. doi: 10.1016/j.it.2022.01.007.

Kim E, Paik D, Ramirez RN, Biggs DG, Park Y, Kwon HK, Choi GB*, Huh JR*. Maternal gut bacteria drive intestinal inflammation in offspring with neurodevelopmental disorders by altering the chromatin landscape of CD4 + T cells. Immunity. 2022 Jan 11. doi: 10.1016/j.immuni.2021.11.005.

2021:

Li W, Hang S, Fang Y, Bae S, Zhang Y, Zhang M, Wang G, McCurry MD, Bae M, Paik D, Franzosa EA, Rastinejad F, Huttenhower C, Yao L, Devlin AS*, Huh JR*. A bacterial bile acid metabolite modulates Treg activity through the nuclear hormone receptor NR4A1. Cell Host Microbe. 2021 Sep 8. doi: 10.1016/J.chom.2021.07.013

2020:

Kalish BT*, Kim E, Finander B, Duffy EE, Kim H, Gilman CK, Yim YS, Tong L, Kaufman RJ, Griffith EC, Choi GB, Greenberg ME*, Huh JR*. Maternal immune activation in mice disrupts proteostasis in the fetal brain. Nat Neurosci. 2020 Dec 23. doi: 10.1038/s41593-020-00762-9. 

2019:

Reed MD, Yim YS, Wimmer RD, Kim H, Ryu C, Welch GM, Andina M, King HO, Waisman A, Halassa MM, Huh JR*, Choi GB*. IL-17a promotes sociability in mouse models of neurodevelopmental disorders. Nature. 2019 Dec 18. doi: 10.1038/s41586-019-1843-6.

Hang S, Paik D, Yao L, Kim E, Jamma T, Lu J, Ha S, Nelson BN, Kelly SP, Wu L, Zheng Y, Longman RS, Rastinejad F, Devlin AS, Krout MR, Fischach MA*, Littman DR*, Huh JR*. Bile acid meetabolites control TH17 and Treg cell differentiation. Nature. 2019 . Dec;576(7785):142-148. doi: 10.1038/s41586-019-1785-z. Epub 2019 Nov 27. PMID:31776512

Huh JR*, Veiga-Fernandes H*. Neuroimmune circuits in inter-organ comunication. Nat Rev Immunol. 2019 Dec 17. doi: 10.1038/s41577-019-0247-z. [Epub ahead of print] Review. PMID: 31848462

Lai NY, Musser MA, Pinho-Ribeiro FA, Baral P, Jacobson A, Ma P, Potts DE, Chen Z, Paik D, Soualhi S, Yan Y, Misra A, Goldstein K, Lagomarsino VN, Nordstrom A, Sivanathan KN, Wallrapp A, Kuchroo VK, Nowarski R, Starnbach MN, Shi H, Surana NK, An D, Wu C, Huh JR, Rao M, Chiu IM. Gut-Innervating Nociceptor Neurons Regulate Peyer's Patch Microfold Cells and SFB Levels to Mediate Salmonella Host Defense. Cell. 2019 Dec 3. pii: S0092-8674(19)31270-X. doi: 10.1016/j.cell.2019.11.014.

2017:

Yim YS, Park A, Berrios J, Pascual L, Soares N, Kim JY, Kim S, Kim H, Waisman A, Littman D, Harnett MT, Wickersham IR, Huh JR*, Choi GB*. Reversing behavioral abnormalities in mice exposed to maternal inflammation. Nature. 2017 doi:10.1038/nature23909 

Kim S, Kim HJ, Yim YS, Ha S, Atarashi K, Tan TG, Longman RS, Honda K, Littman DR, Choi GB*, Huh JR*. Maternal gut bacteria promote neurodevelopmental abnormalities in mouse offspring. Nature. 2017 doi:10.1038/nature23910.

2016:

Choi GB, Yim YS, Wong H, Kim S, Kim H, Kim SV, Hoeffer CA*, Littman DR*, Huh JR*. The maternal interleukin-17a pathway in mice promotes autism-like phenotypes in offspring. Science. 2016 Feb 26;351(6276):933-9. PubMed PMID: 26822608; PubMed Central PMCID: PMC4782964.

The complete list of research publications by the Huh Lab