Publications

2015 - Current

Tusi BK, Wolock SL, Weinreb C, Hwang Y, Hidalgo D, Zilionis R, Waisman A, Huh JR, Klein AM*, Socolovsky M*. Population snapshots predict early haematopoietic and erythroid hierarchies. Nature. 2018 Feb 21. doi: 10.1038/nature25741. PMID: 29466336

Kim JH, Lee E, Friedline RH, Suk S, Jung DY, Dagdeviren S, Hu X, Inashima K, Noh HL, Kwon JY, Nambu A, Huh JR, Han MS, Davis RJ, Lee AS, Lee KW, Kim JK. Endoplasmic reticulum chaperone GRP78 regulates macrophage function and insulin resistance in diet-induced obesity. FASEB J. 2017 Dec 14. pii: fj.201701017R. doi: 10.1096/fj

Choi YS, Jung MK, Lee J, Choi SJ, Choi SH, Lee HW, Lee JJ, Kim HJ, Ahn SH, Lee DH, Kim W, Park SH, Huh JR, Kim HP, Park JY, Shin EC. Tumor Necrosis Factor-producing T-regulatory Cells are Associated With Severe Liver Injury in Patients With Acute Hepatitis A. Gastroenterology. 2017 Dec 8. pii: S0016-5085(17)36685-4. doi: 10.1053/j.gastro

Yim YS, Park A, Berrios J, Pascual L, Soares N, Kim JY, Kim S, Kim H, Waisman A, Littman D, Harnett MT, Wickersham IR, Huh JR*, Choi GB*. Reversing behavioral abnormalities in mice exposed to maternal inflammation. Nature. 2017 doi:10.1038/nature23909 

Kim S, Kim HJ, Yim YS, Ha S, Atarashi K, Tan TG, Longman RS, Honda K, Littman DR, Choi GB*, Huh JR*. Maternal gut bacteria promote neurodevelopmental abnormalities in mouse offspring. Nature. 2017 doi:10.1038/nature23910.

Silverstein NJ, Huh JR. Interleukin-17: Why the worms squirm. Immunity. 2017 46(3): 347-349. PMID: 28329701.

Guerra ES, Lee CK, Specht CA, Yadav B, Huang H, Akalin A, Huh JR, Mueller C, Levitz SM. Central Role of IL-23 and IL-17 Producing Eosinophils as Immunomodulatory Effector Cells in Acute Pulmonary Aspergillosis and Allergic Asthma. PLoS Pathog. 2017 Jan 17;13(1):e1006175. doi:10.1371/journal.ppat.1006175

Choi GB, Yim YS, Wong H, Kim S, Kim H, Kim SV, Hoeffer CA*, Littman DR*, Huh JR*. The maternal interleukin-17a pathway in mice promotes autism-like phenotypes in offspring. Science. 2016 Feb 26;351(6276):933-9. PubMed PMID: 26822608; PubMed Central PMCID: PMC4782964.

Sellars M*, Huh JR*, Day K, Issuree PD, Galan C, Gobeil S, Absher D, Green MR, Littman DR. Regulation of DNA methylation dictates Cd4 gene expression during development of helper and cytotoxic T cell lineages. Nature immunology. 2015 Jul;16(7):746-54. PubMed PMID: 26030024; PubMed Central PMCID: PMC4474743.

 

1999 - 2014

Longman, RS., Diehl, GE., Victorio,D., Huh, JR., Galan, C., MiraldiE., Swaminath,A., Bonneau, R., Scherl, EJ., Littman, DR. CX3CR1+ Mononuclear Phagocytes Support Colitis-Associated Innate Lymphoid Cell Production of IL-22. Journal of Experimental Medicine. 2014 Jul 14. pii: jem.20140678.

Huh, JR., Englund, EE., Wang, H., Huang, H., Huang, P., Rastinejad, F., Inglese, J., Austin, CP., Johnson, RL., Huang, W., Littman, DR. (2013). Identification of Potent and Selective Diphenylpropanamide RORg Inhibitors. ACS Med Chem Lett. 4(1):79-84. PMCID: PMC3770298.

Huh, JR., Littman, DR. (2012). Small molecule inhibitors of RORgt: Targeting Th17 cells and other applications. Eur J Immunol. 42(9):2232-7. PMCID: PMC3609417. - Review

Huh JR, Leung MW, Huang P, Ryan DA, Krout MR, Malapaka RR, Chow J, Manel N, Ciofani M, Kim SV, Cuesta A, Santori FR, Lafaille JJ, Xu HE, Gin DY, Rastinejad F, Littman DR. Digoxin and its derivatives suppress TH17 cell differentiation by antagonizing RORγt activity. Nature. 2011 Apr 28;472(7344):486-90. PubMed PMID: 21441909; PubMed Central PMCID: PMC3172133.  

Huh, JR., Foe, I., Muro, I., Chen, CH., Seol, JH., Yoo, SJ., Guo, M., Park, JM., Hay, BA. (2007). The Drosophila inhibitor of apoptosis (IAP) DIAP2 is dispensable for cell survival, required for the innate immune response to gram-negative bacterial infection, and can be negatively regulated by the reaper/hid/grim family of IAP-binding apoptosis inducers. J Biol Chem. 282(3):2056-68. PMID: 17068333

Muro, I., Berry, DL., Huh, JR., Chen, CH., Huang, H., Yoo, SJ., Guo, M., Baehrecke, EH., Hay, BA. (2006). The Drosophila caspase Ice is important for many apoptotic cell deaths and for spermatid individualization, a nonapoptotic process. Development. 133(17):3305-15. PMID: 16887831.

Clark, IE., Dodson, MW., Jiang, C., Cao, JH., Huh, JR., Seol, JH., Yoo, SJ., Hay, BA., Guo, M. (2006). Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin. Nature. 441(7097):1162-6. PMID: 16672981.

Yan, N., Huh, JR., Schirf, V., Demeler, B., Hay, BA., Shi, Y. (2006). Structure and activation mechanism of the Drosophila initiator caspase Dronc. J Biol Chem. 281(13):8667-74. PMID: 16446367.

Hay, BA., Huh, JR., Guo M. (2004). The genetics of cell death: approaches, insights and opportunities in Drosophila. Nat. Rev. Genetics. 5(12):911-922. PMID: 15573123. – Review

Huh, JR., Guo, M., Hay, BA. (2004). Compensatory proliferation induced by cell death in the Drosophila wing disc requires activity of the apical cell death caspase Dronc in a nonapoptotic role. Curr Biol. 14(14):1262-6. PMID: 15268856.

Huh, JR., Vernooy, SY., Yu, H., Yan, N., Shi, Y., Guo, M., Hay, BA. (2004). Multiple apoptotic caspase cascades are required in nonapoptotic roles for Drosophila spermatid individualization. PLoS Biol. 2(1):E15. PMCID: PMC300883.

Chai, J., Yan, N., Huh, JR., Wu, JW., Li, W., Hay, BA., Shi, Y. (2003). Molecular mechanism of Reaper-Grim-Hid-mediated suppression of DIAP1-dependent Dronc ubiquitination. Nat Struct Biol. 10(11):892-8. PMID: 14517550.

Olson, MR., Holley, CL., Yoo, SJ., Huh, JR., Hay, BA., Kornbluth, S. (2003). Reaper is regulated by IAP-mediated ubiquitination. J Biol Chem. 278(6):4028-34. PMID: 12446669.

Huh, JR., Hay, BA. (2002). Apoptosis: sculpture of a fly’s head. Nature. 418(6901):926-8. PMID: 12198529. – Review

Yoo, SJ*., Huh, JR*., Muro, I., Yu, H., Wang, L., Wang, SL., Feldman, RM., Clem, RJ., Müller, HA., Hay, BA. (2002). Hid, Rpr and Grim negatively regulate DIAP1 levels through distinct mechanisms. Nat Cell Biol. 4(6):416-24. PMID: 12021767. – *Equally contributed

Dorstyn, L., Read, S., Cakouros, D., Huh, JR., Hay, BA, Kumar, S. (2002). The role of cytochrome c in caspase activation in Drosophila melanogaster cells. J Cell Biol. 156(6):1089-98. PMCID: PMC2173478.

Huh, JR., Park, JM., Kim, M., Carlson, BA., Hatfield, DL., Lee, BJ. (1999). Recruitment of TBP or TFIIB to a promoter proximal position leads to stimulation of RNA polymerase II transcription without activator proteins both in vivo and in vitro. Biochem Biophys Res Commun. 256(1):45-51. PMID: 10066420

Cao, Y., Kang, HL., Xu, X., Wang, M., Dho, SH., Huh, JR., Lee, BJ., Kalush, F., Bocskai, D., Ding, Y., Tesmer, JG., Lee, ME., Jurecic, V., Baldini, A., Weier, HU., Doggett, NA., Simon, MI., Adams, MD., and Kim, UJ. (1999) A 12-Mb complete coverage BAC contig map in human chromosome 16p13.1-p11.2. Genome Research 9(8), 763-774.